Cart
sales@molnova.com
Home - Products - Neuroscience - GluR - Pomaglumetad methionil hydrochloride

Pomaglumetad methionil hydrochloride

CAS No. 635318-26-2

Pomaglumetad methionil hydrochloride( —— )

Catalog No. M35610 CAS No. 635318-26-2

Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 322 Get Quote
5MG 511 Get Quote
10MG 739 Get Quote
25MG 1086 Get Quote
50MG 1490 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Pomaglumetad methionil hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity.
  • Description
    Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.
  • In Vitro
    Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM.LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM.
  • In Vivo
    Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) .Animal Model:Male Fischer rats (approximately 250 g) Dosage:3 mg/kg, 10 mg/kg, and 300 mg/kg Administration:Orally; once daily for 7 days Result:Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    635318-26-2
  • Formula Weight
    402.87
  • Molecular Formula
    C12H19ClN2O7S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (62.05 mM; Ultrasonic )
  • SMILES
    Cl.[H][C@@]12[C@@H](C(O)=O)[C@]1([H])S(=O)(=O)C[C@@]2(NC(=O)[C@@H](N)CCSC)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Valiglurax

    Valiglurax (VU2957), also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties across species.

  • CX614

    CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.

  • CNQX

    CNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors respectively).

Sign In Join Free